人类脑转移的基因组表征可确定转移性肺腺癌
2021-5-10 来源：本站原创 浏览次数：次SCI
22Apr
Genomiccharacterizationofhumanbrainmetastasesidentifiesdriversofmetastaticlungadenocarcinoma
ShihDavidJH,NayyarNaema,BihunIvannaetal.Genomiccharacterizationofhumanbrainmetastasesidentifiesdriversofmetastaticlungadenocarcinoma.[J].Nat.Genet.,,52:-.
Brainmetastasesfromlungadenocarcinoma(BM-LUAD)frequentlycausepatientmortality.Toidentifygenomicalterationsthatpromotebrainmetastases,weperformedwholeexomesequencingof73BM-LUADcases.Usingcase-controlanalyses,wediscoveredcandidatedriversofbrainmetastasisbyidentifyinggeneswithmorefrequentcopy-numberaberrationsinBM-LUAD
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