转移性非小细胞肺癌血浆基因分型及个体化治

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SCI

19October

ClinicalImplicationsofPlasma-BasedGenotypingWiththeDeliveryofPersonalizedTherapyinMetastaticNon–SmallCellLungCancer

AggarwalC,ThompsonJC,BlackTA,etal.Clinicalimplicationsofplasma-basedgenotypingwiththedeliveryofpersonalizedtherapyinmetastaticnon–smallcelllungcancer.JAMAoncology.

CorrespondingAuthor:EricaL.Carpenter,MBA,PhD,DivisionofHematology-Oncology,DepartmentofMedicine,UniversityofPennsylvaniaPerelmanSchoolofMedicine,8-SouthPavilion,8thFloor,CivicCenterBlvd,Philadelphia,PA19(erical

IMPORTANCE重要性

Theclinicalimplicationsofaddingplasma-basedcirculatingtumorDNAnext-generationsequencing(NGS)totissueNGSfortargetablemutationdetectioninnon–smallcelllungcancer(NSCLC)havenotbeenformallyassessed.

尚未正式评估将基于血浆的循环肿瘤DNA二代测序（NGS）添加至组织NGS以用于非小细胞肺癌（NSCLC）中的靶向突变检测的临床意义。

OBJECTIVE目标

TodeterminewhetherplasmaNGStestingwasassociatedwithimprovedmutationdetectionandenhanceddeliveryofpersonalizedtherapyinareal-worldclinicalsetting.

确定血浆NGS测试是否与改进的突变检测和在现实世界临床环境中增强个性化治疗的传递相关。

DESIGN,SETTING,PARTICIPANTS设计，设置和参与者

ThisprospectivecohortstudyenrolledpatientswithmetastaticNSCLCwhohadplasmatestingorderedaspartofroutineclinicalmanagement.PlasmaNGSwasperformedusinga73-gene