一个对骨转移放射治疗的转移性肺癌患者的生

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SCI

18October

DevelopmentandValidationofaNomogramforAssessingSurvivalinPatientsWithMetastaticLungCancerReferredforRadiotherapyforBoneMetastases

YapW,ShihM,KuoC,etal.Developmentandvalidationofanomogramforassessingsurvivalinpatientswithmetastaticlungcancerreferredforradiotherapyforbonemetastases.JAMANetworkOpen;1:e.

CorrespondingAuthor:Ngan-MingTsang,MD,ScD,DepartmentofRadiationOncology,LinkouChangGungMemorialHospital,5Fu-ShinSt,Kwei-Shan,TaoyuanCity,Taiwan(vstsang

IMPORTANCE重要性

Asurvivalpredictionmodelforpatientswithbonemetastasesarisingfromlungcancerwouldbehighlyvaluable.

对于肺癌而引起骨转移患者的生存预测模型是非常有价值的。

OBJECTIVE目标

Todevelopandvalidateanomogramforassessingthesurvivalprobabilityofpatientswithmetastaticlungcancerreceivingradiotherapyforosseousmetastases.

开发和验证一种用于评估转移性肺癌患者在骨转移治疗中存活的概率。

DESIGN,SETTING,PARTICIPANTS设计，设置和参与者

Inthisprognosticstudy,theputativeprognosticindicatorsforconstructingthenomogramwereidentifiedusingmultivariableCoxregressionanalysiswithbackwardeliminationandmodelselectionbasedontheAkaikeinformationcriterion.

在这一预后研究中，利用后向消元的多变量Cox回归分析和基于Akaike信息准则的模型选择，确定了构造列线图的假定预后指标

DESIGN,SETTING,PARTICIPANTS设计，设置和参与者

Inthisprognosticstudy,theputativeprognosticindicatorsforconstructingthenomogramwereidentifiedusingmultivariableCoxregressionanalysiswithbackwardeliminationandmodelselectionbasedontheAkaikeinformationcriterion.

在这一预后研究中，利用后向消元的多变量Cox回归分析和基于Akaike信息准则的模型选择，确定了构造列线图的假定预后指标

Thenomogramwassubjectedtointernal(bootstrap)andexternalvalidation;itscalibrationanddiscriminativeabilitywereevaluatedwithcalibrationplotsandtheUnoCstatistic,respectively.ThetrainingandvalidationsetcohortswerefromatertiarymedicalcenterinnorthernTaiwanandatertiaryinstitutioninsouthernTaiwan,respectively.

列线图受到内部（引导）和外部验证的影响；分别用标定图和UnoC统计量对其标定和鉴别能力进行了评估。培训和验证组分别来自台湾北部的三级医疗中心和台湾南部的高等教育机构。

Thetrainingset